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Home » Forums » Module Discussion » Gene Therapy

About a disease

Submitted by Safna on Thu, 03/08/2012 - 01:28
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There is an auto immune disease named SLE (SYSTEMIC LUPUS ERYTHROSIS) . Can gene therapy or stem cell cure this disease? Or it can clear the butterfly marks on the skin that may arise as a part of this disease? ? ?

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#1 We are looking into this for

Submitted by TechNyou on Fri, 03/16/2012 - 12:56.
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We are looking into this for you, but essentially, if the disease is caused by a faulty gene then there is the potential to treat it with gene therapy, though at this stage of our knowledge such treatments are restricted to single gene SNP (single nucleotide polymorphisms) mutations. The other question, is of course, if it is possible to treat this disease with gene therapy, is there anyone doing the research? As for stem cells, that usually involves replacing damaged cells and most of this research with the exception of bone marrow transport stuff is still at the lab bench rather than the clinic. Jason TechNyou

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#2 OK, we have a response. The

Submitted by TechNyou on Fri, 03/16/2012 - 14:04.
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OK, we have a response. The following is from Brett Drummond, communication assistant at TechNyou, and PhD student at Bio21 Institute: Fortuitously, his laboratory colleague is working on Lupus.

The problem with SLE, as with a lot of autoimmune diseases, is that what actually causes the body's immune system to attack itself is currently unknown. Therefore, current management strategies revolve around the treatment of symptoms, whilst a cure remains elusive.

SLE seems to be the result of interplay between both genetic and environmental risk factors. Although certain alleles of genes (such as some Class I and Class II molecules of the Major Histocompatibility Complex - MHC) appear to increase the risk of developing the disease, no one polymorphism in particular can be attributed to causing disease. This makes it unlikely that gene therapy will, at this stage anyway, be an appropriate course of action to treat or cure SLE.

Similarly, stem cells are useful in the regeneration of damaged tissue etc, however, the major cause of symptoms in SLE is from the inflammatory response caused by the immune reaction and by the deposition of antibody complexes around the body.

At this point, it is difficult to say where a cure will come from, though what is definite is that first the cause of disease must be identified. Based on what is known already, we can hypothesise that a cure will come from somehow altering the immune response to avoid this self-reactivity.

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#3 OK, we have a response. The

Submitted by michealfernedus on Fri, 11/16/2012 - 08:44.
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OK, we have a response. The following is from Brett Drummond, communication assistant at TechNyou, and PhD student at Bio21 Institute: Fortuitously, his laboratory colleague is working on Lupus.

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#4 Hmm, I'm not sure about that

Submitted by fg4234 on Wed, 11/21/2012 - 01:14.
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Hmm, I'm not sure about that one.
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#5 I am so glad that I took the

Submitted by lizajennifer (not verified) on Wed, 11/21/2012 - 05:51.
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#6 I wanted to inform you for

Submitted by sam on Mon, 01/28/2013 - 16:26.
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Submitted by sharon199 on Thu, 02/07/2013 - 20:32.
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Submitted by kelly123 on Wed, 04/24/2013 - 17:41.
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Submitted by Tommy123 on Sat, 04/27/2013 - 04:33.
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Submitted by rosejennifer on Sat, 04/27/2013 - 21:42.
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Submitted by eavedrop44 on Mon, 04/29/2013 - 15:21.
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#12 I have never heard of this

Submitted by Richak on Thu, 05/09/2013 - 02:17.
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I have never heard of this disease. Will search more info about it.
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#13 I have no clue about what

Submitted by Sandra on Thu, 05/09/2013 - 02:54.
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I have no clue about what that disease is..
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#14 This is a great inspiring

Submitted by sadiaromi on Thu, 05/09/2013 - 04:50.
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#15 I have no clue about this

Submitted by Stacey on Thu, 05/09/2013 - 17:45.
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I have no clue about this one...
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#16 There is an auto immune

Submitted by SarahBenedict on Sun, 05/12/2013 - 15:40.
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There is an auto immune disease named SLE (SYSTEMIC LUPUS ERYTHROSIS) . Can gene therapy or stem cell cure this disease? Or it can clear the butterfly marks on the skin that may arise as a part of this disease? ? ?

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#17 I am very much positive that

Submitted by chrisjames on Mon, 05/13/2013 - 08:14.
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I am very much positive that this disease can be cured, but with so difficulty, can be curable

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#18 I wanted to inform you for

Submitted by usman8 on Mon, 05/13/2013 - 14:12.
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#19 What is this auto immune

Submitted by chrisjames on Mon, 05/13/2013 - 17:03.
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What is this auto immune disease named SLE (SYSTEMIC LUPUS ERYTHROSIS), how it can be genetic disease, plz provide us with some statistics.

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#20 is this necessary for the

Submitted by chrisjames on Mon, 05/13/2013 - 20:00.
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is this necessary for the person got this disease that there must be butterfly kind of scratches in its skin?

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#21 I have never heard of this

Submitted by abhishek on Mon, 05/13/2013 - 21:05.
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I have never heard of this disease..Will look for more info.
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#22 Gene therapy is the cure of

Submitted by chrisjames on Tue, 05/14/2013 - 01:31.
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Gene therapy is the cure of the disease but reluctant to be more expensive to bare.

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#23 I am agree that the stem cell

Submitted by chrisjames on Tue, 05/14/2013 - 05:17.
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I am agree that the stem cell diffusion can be used to cure this disease, research required in the field.

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#24 There is lot more to be

Submitted by chrisjames on Tue, 05/14/2013 - 22:56.
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There is lot more to be described to proper information for the peoples, I think it will need very much research in it.

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#25 i like this post very much

Submitted by seoniyam on Sat, 05/18/2013 - 15:38.
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#27 Your article shows you have a

Submitted by nobelboy on Mon, 05/20/2013 - 03:08.
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#28 I was doing a project and for

Submitted by nobelboy on Mon, 05/20/2013 - 03:08.
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#29 A disease is an abnormal

Submitted by Kathleen on Mon, 05/20/2013 - 19:25.
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#30 we should think about health

Submitted by Arjun on Mon, 05/20/2013 - 23:39.
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we should think about health and take care . keep clean as well as we do not eat food on road .
It is harmful for heath . we should daily exercise and playing any sport.

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Submitted by usman8 on Wed, 05/22/2013 - 20:36.
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#33 It's really pleasure to read

Submitted by nobelboy on Fri, 05/24/2013 - 04:47.
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